CT-Reg is a comprehensive, 2-in-1 formulation designed to provide both thyroid and cardiovascular support. Each clinically-researched ingredient was carefully selected to support and balance thyroid function by helping convert T4 (the inactive thyroxine thyroid hormone) into T3 (the more bioactive triiodothyronine thyroid hormone). CT-Reg also supports the binding of these thyroid hormones to its receptor site. In addition to thyroid support, the key ingredients in CT-Reg have also been shown to significantly improve many key lipid markers associated with cardiovascular health. This includes helping improve cholesterol, LDL, HDL, triglycerides, fasting blood sugar, hemoglobin A1C (Hg-A1C) and fasting insulin levels.
Vitamins & Minerals (Vitamin B6, Magnesium, Zinc, Selenium, Copper)
Vitamin B6
Vitamin B6 (pyridoxine) is required for more than 60 different enzymatic reactions, including supporting the Thyroid peroxidase (TPO) enzyme that is needed in order to make thyroid hormone. 1
Magnesium Glycinate
Magnesium is a cofactor required in over 300 enzymatic reactions 2-4, including those associated with the thyroid gland and heart. Magnesium is required by both the Thyroid peroxidase (TPO) enzyme needed to make thyroid hormone as well as the deiodinases enzymes responsible for converting inactive T4 into active T3 hormone. Magnesium glycinate is a superior form of magnesium shown to absorb much better than conventional forms of magnesium. 5-6
Zinc, Copper & Selenium
Zinc and selenium are essential trace minerals that act as coenzymes in many essential reactions in the body. They are both required by the deiodinases enzymes that convert T4 into active T3. Research has shown that zinc supplementation was able to restore T3 levels in patients with normal T4 and low T3.7 In addition to contributing to decreased T4 to T3 conversion, selenium supplementation has also been shown to help decrease thyroid peroxidase (TPO) antibodies that are associated with autoimmune thyroid.8
Copper
Copper is a trace mineral that acts as an essential cofactor for oxidation-reduction reactions in the body. It is included in the formulation in order to protect against a zinc-induced copper depletion, due to the delicate balance needed between zinc and copper in the body.
Milk Thistle Seed Extract (Silybum marianum)
Milk thistle has been used for centuries as a botanical medicine for a wide range of clinical applications. It is most well-known for its beneficial effects on the liver, which is a key organ involved in converting T4 hormone into its active T3 form. It also provides dual antioxidant support in the body, as it is able to directly scavenge free radicals as well as increase glutathione production in the body, a powerful endogenous antioxidant.9 This dual antioxidant support will assist with quenching free radicals and reduce inflammation, which can lead to increased thyroid receptor activity and enhanced thyroid hormone-receptor binding In addition to providing liver and antioxidant support, milk thistle has also has shown to be a powerful lipo-protective and glycemic regulating compound. In one randomized double-blind clinical trial evaluating type 2 diabetic patients has shown that 600 mg a day of milk thistle over four months caused the reduction of the following serum markers: fasting blood sugar 14.7%, hemoglobin A1C 12.8%, insulin 25%, total cholesterol 12%, LDL 12%, triglycerides 25.7%, SGOT 22.7% and SGPT 36.8%. 9
Guggulipid (Guggul Oleo Gum Resin Extract)
Guggulipid has been used as a staple in Indian Ayurvedic medicine for nearly 3,000 years and has many therapeutic uses including supporting thyroid function by helping to protect against lipid peroxidation in the liver, the principal site of T4-T3 conversion. In addition, guggul extract has been shown to have thyroid-stimulating action by increasing the activities of TPO enzymes as well as increase iodine uptake by the thyroid gland.10-11 Guggulipid has also been shown to help support a healthy lipid profile by reducing total cholesterol, triglycerides, LDL and lipid peroxide levels. In one double-blind placebo controlled trial in hypercholesterolemia patients, guggul supplementation (50 mg guggulsterones twice daily) was able to improve the following markers during the 6 month trial period: total cholesterol 11.7%, LDL 12.5%, triglycerides 12.0% and lipid peroxide levels (oxidative stress marker) by 33.3%.12 Other double-blind research showed guggul’s ability to outperform the drug clofibrate in lowering total cholesterol by the end of the 12 week trial period.13
N-Acetyl-L-Cysteine (NAC)
NAC is an amino acid that is essential for an abundant antioxidant supply, as it acts as a precursor to one of the most important antioxidants, glutathione.14 In a randomized placebo-controlled clinical trial studying patients with low levels of T3 and high reverse T3 (RT3), NAC administration was shown to decrease serum RT3 whereas no significant changes in serum RT3 levels were observed in the placebo group.15
Policosanol
Policosanol is an extract from sugar cane that has been well researched for its many benefits in supporting cardiovascular function, including improving serum lipids, helping to reduce LDL oxidation, and decreasing platelet aggregation. In one randomized, double-blind trial that was controlled for dietary influences, subjects experienced a significant drop in total cholesterol (12.7%) and triglycerides (13.6%) while increasing HDL (+14.4%) after eight weeks taking 1g of Omega 3 fatty acids (O3FA) and 5mg/day of policosanol. Policosanol has been shown to be superior at improving total cholesterol, LDL and HDL levels compared to O3FA alone.
Unlike the mechanism of action of statin drugs, which work by competitively inhibiting the 3-hydroxy-3- methylglutaryl Coenzyme A (HMG-CoA), the rate-limiting step in cholesterol synthesis, policosanol appears to cause decreased cholesterol synthesis by increasing the degradation of HMG-CoA).16-17
Other research has shown policosanol’s ability to improve LDL metabolism by increasing the binding of the LDL molecule, its uptake into cells, and its degradation in human fibroblasts.18
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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. |
WARNING: Consuming this product can expose you to chemicals including lead, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov/food. |
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SUPPLEMENT FACTS |
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Serving Size: 4 Capsules |
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Servings per Container: 30 |
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AMOUNT PER SERVING |
% Daily Value |
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Vitamin B6 (as Pyridoxal-5-Phosphate) |
2 |
mg |
118% |
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Magnesium (as Magnesium Glycinate) |
50 |
mg |
12% |
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Zinc (as Zinc Picolinate) |
10 |
mg |
91% |
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Selenium (as L-Selenomethionine) |
150 |
mcg |
273% |
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Copper (as Copper Bisglycinate Chelate) |
0.2 |
mg |
22% |
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Milk Thistle Seed Extract (standardized to 80% Silymarin) |
600 |
mg |
* |
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Guggul Oleo Gum Resin Extract (standardized to 10% Guggul Sterones) |
200 |
mg |
* |
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N-Acetyl-L-Cysteine |
200 |
mg |
* |
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Policosanol |
5 |
mg |
* |
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† Daily Value not established Other Ingredients: Vegeterian capsule (hypromellose), Microcrystalline Cellulose |
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Suggested Use:
As a dietary supplement, take four (4) capsules per day preferably in two divided doses or as directed by your health care professional.
Caution:
As with any dietary supplement, consult your healthcare practitioner before using this product, especially if you are pregnant, nursing, anticipate surgery, take any medication or are otherwise under medical supervision.
Formulated to Be Free of Allergens Derived From:
Wheat, soy, dairy, eggs, fish, crustacean shellfish, tree nuts, peanuts, artificial preservatives, sweeteners, color and flavors.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
1. Murray MT. Encyclopedia of Nutritional Supplements.(1996); Prima Publishing: Rocklin, CA.
2. Committee to Review Dietary Reference Intakes for Vitamin D and Calcium, Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: National Academy Press, 2010.
3. Institute of Medicine (IOM). Food and Nutrition Board. Dietary Reference Intakes: Calcium, Phosphorus, Magnesium, Vitamin D and Fluoride. Washington, DC: National Academy Press, 1997.
4. Rude RK. Magnesium. In: Coates PM, Betz JM, Blackman MR, Cragg GM, Levine M, Moss J, White JD, eds. Encyclopedia of Dietary Supplements. 2nd ed. New York, NY: Informa Healthcare; 2010:527-37.
5. Spasov, A. A., Petrov, V. I., Iezhitsa, I. N., Kravchenko, M. S., Kharitonova, M. V., & Ozerov, A. A. (2010). Comparative study of magnesium salts bioavailability in rats fed a magnesium-deficient diet. Vestnik Rossiiskoi akademii meditsinskikh nauk, (2), 29-37.
6. Schuette, S. A., Lashner, B. A., & Janghorbani, M. (1994). Bioavailability of magnesium diglycinate vs magnesium oxide in patients with ileal resection. Journal of Parenteral and Enteral Nutrition, 18(5), 430-435.
7. Nishiyama S, Futagoishi-Suginohara Y, Matsukura M, Nakamura T, Higashi A, Shinohara M, Matsuda I. Zinc supplementation alters thyroid hormone metabolism in disabled patients with zinc deficiency. J Am Coll Nutr; 1994 Feb;13(1):62-7.
8. Pizzorno JE, Murray MT. The Clinician’s Handbook of Natural Medicine. 2nd Ed. 2008.
9. Surai, P. F. (2015). Silymarin as a natural antioxidant: an overview of the current evidence and perspectives. Antioxidants, 4(1), 204-247.
10. Tripathi YB, Malhotra OP, Tripathi SN. Thyroid Stimulating Action of Z-Guggulsterone Obtained from Commiphora mukul. Planta Med. 1984 Feb;50(1):78-80.
11. Singh AK, Prasad GC, Tripathi SN. In vitro studies on thyrogenic effect of commiphora mukul (guggulu). Anc Sci Life. 1982 Jul-Sep; 2(1): 23–28.
12. Singh, R. B., Niaz, M. A., & Ghosh, S. (1994). Hypolipidemic and antioxidant effects of Commiphora mukul as an adjunct to dietary therapy in patients with hypercholesterolemia. Cardiovascular drugs and therapy, 8(4), 659-664.
13. Nityanand, S., Srivastava, J. S., & Asthana, O. P. (1989). Clinical trials with gugulipid. A new hypolipidaemic agent. The Journal of the Association of Physicians of India, 37(5), 323-328.
14. Yim CY, et al. Use of N-acetyl cysteine to increase intracellular glutathione during the induction of antitumor responses by IL-2. J Immul 1994;152:5796-5805.
15. Vidart J, Wajner SM, Leite RS. N-acetylcysteine administration prevents nonthyroidal illness syndrome in patients with acute myocardial infarction: a randomized clinical trial. J Clin Endocrinol Metab 2014;99(12):4537-45
16. Castano, G., et al. "Effects of addition of policosanol to omega-3 fatty acid therapy on the lipid profile of patients with type II hypercholesterolaemia." Drugs in R & D 6.4 (2005): 207-219.
17. Menendez R, Amor AM, Gonzalez R, et al.Effect of policosanol on the hepatic cholesterol biosynthesis of normocholesterolemic rats.Biol Res 1996;29:253-257.3.
18. Menendez R, Amor AM, Rodeiro I, et al.Policosanol modulates HMG-CoA reductase activity in cultured fibroblasts. Arch Med Res 2001;32:8-12.
19. Menendez R, Fernandez SI, Del Rio A, et al. Policosanol inhibits cholesterol biosynthesis and enhances low density lipoprotein processing in cultured human fibroblasts. Biol Res 1994;27:199-203.
