Vit B12 is essential in the production of red blood cells and therefore how oxygen is carried throughout the body. In addition to helping get oxygen to the cells, vitamin B12 also supports energy production since it’s a cofactor for enzymes involved in the Kreb’s cycle which leads to the production of adenosine triphosphate (ATP), the energy currency of the cell
Vit B12 is also essential for the development, myelination, and function of the central nervous system, helping form the myelin sheath around neurons. Acting as a critical brain nutrient, it’s involved in the synthesis of neurotransmitters that send signals to the rest of the body for many important functions.
Alongside folate, vitamin b12 regulates homocysteine metabolism which is a protein that has been linked to mood and cardiovascular issues if elevated in the blood. Due to its role in methylation, it’s essential for many functions in the body including gene expression, DNA repair & maintenance, and nervous system health.
Vit B12 deficiency is believed to be one of the most common nutrient deficiencies in the world. Populations that are most at risk include the elderly, vegetarians/vegans, those with gastrointestinal disorders or who’ve had intestinal surgeries, individuals with pernicious anemia, and those taking antibiotic and/or stomach acid-lowering medications frequently.5-10 Prolonged vitamin B-12 deficiency can lead to fatigue, anemia, dysbiosis, muscle weakness, nerve damage, and mood disturbances.
Aceva’s Active B Liquid features a unique ratio of the two biologically active forms of vit B12 called methylcobalamin and adenosylcobalamin in a highly absorbable sublingual form. The majority of other vit b12 products contain cyanocobalamin form which requires the body to convert it to one of the active forms in the liver. Cyanocobalamin also contains a cyanide molecule and can potentially be toxic to the body. Other products may only contain methylcobalamin which is beneficial but does not provide the adenosylcobalamin form which is the “mitochondrial ready” form. The active forms of B12 have been shown to bypass several steps in the absorption cycle which is a benefit for those with compromised digestion. Methyl B12 & adenosyl B12 absorb, retain and increase tissue concentration much better than the cyanocobalamin form of vit B12.12 Their combined use offers a myriad of benefits that would not be able to be achieved alone.
Methylcobalamin contains a methyl group beneficial for methylation reactions including those needed for DNA repair and maintenance, homocysteine metabolism, neurotransmitter production, fetal development and nervous system health. It’s been shown to bypass several potential issues in the intestinal absorption cycle which means it has higher bioavailability.13
Adenosylcobalamin is the mitochondrial form of vit B12 and is the primary storage form our bodies tuck away in the liver for times of need. Research has shown this form of vit B12 along with carnitine promoted cerebral mass growth, neuronal volume and neocortical layer thickness in the brain and fully restored normal structure of the neocortex in the brain and has been shown to eliminate work rate inconsistencies and improve mental productivity. 14-15
|
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease. |
Suggested Use:
Shake well before each use. Take 5 drops 1-2 x daily on an empty stomach or as directed by your healthcare professional. It’s recommended to take in the morning or early afternoon and wait at least 15 minutes before eating or drinking anything else. For best results, place drops underneath the tongue and hold for 90 seconds and swish it around in your mouth for 30 seconds before swallowing.
Formulated to Be Free of Allergens Derived From:
Wheat, gluten, soy, dairy, eggs, fish, crustacean shellfish, tree nuts, peanuts, artificial preservatives, sweeteners, color and flavors.
Institute of Medicine, Food and Nutrition Board. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B(6), Folate, Vitamin B(12), Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academies Press; 1998.
Carmel R. Cobalamin (vitamin B12). In: Ross AC, Caballero B, Cousins RJ, Tucker KL, Ziegler TR, eds. Modern Nutrition in Health and Disease. 11th ed. Baltimore, MD: Lippincott Williams & Wilkins; 2014:369-89.
Allen LH. Vitamin B12. In: Coates PM, Betz JM, Blackman MR, et al., eds. Encyclopedia of Dietary Supplements. 2nd ed. London and New York: Informa Healthcare; 2010:812-20.
Stabler SP. Vitamin B12. In: Marriott BP, Birt DF, Stallings VA, Yates AA, eds. Present Knowledge in Nutrition. 11th ed. Washington, DC: Elsevier; 2020:257-71.
Allen LH, Miller JW, de Groot L, Rosenberg IH, Smith AD, Refsum H, et al. Biomarkers of Nutrition for Development (BOND): Vitamin B-12 Review. J Nutr 2018;148:1995S-2027S.
Pawlak, Roman, et al. "How prevalent is vitamin B12 deficiency among vegetarians?." Nutrition reviews 71.2 (2013): 110-117.
Wong CW. Vitamin B12 deficiency in the elderly: Is it worth screening? Hong Kong Med J 2015;21:155-64.
Pfisterer KJ, Sharratt MT, Heckman GG, Keller HH. Vitamin B12 status in older adults living in Ontario long-term care homes: pPincidence of deficiency with supplementation as a protective factor. Appl Physiol Nutr Metab 2016;41:219-22.
Allen LH. Vitamin B12. In: Coates PM, Betz JM, Blackman MR, et al., eds. Encyclopedia of Dietary Supplements. 2nd ed. London and New York: Informa Healthcare; 2010:812-20.
Ao M, Tsuji H, Shide K, Kosaka Y, Noda A, Inagaki N, et al. High prevalence of vitamin B-12 insufficiency in patients with Crohn’s disease. Asia Pac J Clin Nutr 2017;26:1076-81.
Anon, Office of dietary supplements - vitamin b12. NIH Office of Dietary Supplements. Available at: https://ods.od.nih.gov/factsheets/Vitaminb12-HealthProfessional/#en5 [Accessed August 17, 2021].
Paul, Cristiana, and David M. Brady. "Comparative bioavailability and utilization of particular forms of B12 supplements with potential to mitigate B12-related genetic polymorphisms." Integrative Medicine: A Clinician's Journal 16.1 (2017): 42.
Kim HI, Hyung WJ, Song KJ, Choi SH, Kim CB, Noh SH. Oral vitamin B12 replacement: an effective treatment for vitamin B12 deficiency after total gastrectomy in gastric cancer patients. Ann Surg Oncol. 2011 Dec;18(13):3711-7. doi: 10.1245/s10434-011-1764-6. Epub 2011 May 10. PMID: 21556950.
Korkina, M. B., G. M. Korchak, and D. I. Medvedev. "Clinico-experimental substantiation of the use of carnitine and cobalamin in the treatment of anorexia nervosa." Zhurnal nevropatologii i psikhiatrii imeni SS Korsakova (Moscow, Russia: 1952) 89.2 (1989): 82-87.
Korkina, M. V., G. M. Korchak, and M. A. Kareva. "Effects of carnitine and cobamamide on the dynamics of mental work capacity in patients with anorexia nervosa." Zhurnal nevropatologii i psikhiatrii imeni SS Korsakova (Moscow, Russia: 1952) 92.2 (1992): 99-102.
